Selective blockade of the discriminative stimulus effects of pentobarbital in pigeons

Seymore Herling, Gail Winger

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The ability of CNS stimulants to block the discriminative effects of pentobarbital was studied in pigeons trained to discriminate IM pentobarbital (5 mg/kg) from saline. Pentobarbital, when administered alone, consistently produced greater than 90% pentobarbital-appropriate responding. The concomitant administration of pentobarbital and increasing doses of bemegride or pentylenetetrazol resulted in a dose-related decrease in pentobarbital-appropriate responses. In contrast, picrotoxin, another CNS stimulant, had little or no effect on pentobarbital-appropriate responding produced by pentobarbital.

Original languageEnglish (US)
Pages (from-to)321-323
Number of pages3
Issue number3
StatePublished - Nov 1981
Externally publishedYes


  • Antagonism
  • Bemegride
  • Drug discrimination
  • Pentobarbital
  • Pentylenetetrazol
  • Picrotoxin
  • Pigeons

ASJC Scopus subject areas

  • Pharmacology


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