Abstract
The ability of CNS stimulants to block the discriminative effects of pentobarbital was studied in pigeons trained to discriminate IM pentobarbital (5 mg/kg) from saline. Pentobarbital, when administered alone, consistently produced greater than 90% pentobarbital-appropriate responding. The concomitant administration of pentobarbital and increasing doses of bemegride or pentylenetetrazol resulted in a dose-related decrease in pentobarbital-appropriate responses. In contrast, picrotoxin, another CNS stimulant, had little or no effect on pentobarbital-appropriate responding produced by pentobarbital.
Original language | English (US) |
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Pages (from-to) | 321-323 |
Number of pages | 3 |
Journal | Psychopharmacology |
Volume | 75 |
Issue number | 3 |
DOIs | |
State | Published - Nov 1981 |
Keywords
- Antagonism
- Bemegride
- Drug discrimination
- Pentobarbital
- Pentylenetetrazol
- Picrotoxin
- Pigeons
ASJC Scopus subject areas
- Pharmacology