Select: The next prostate cancer prevention trial

E. A. Klein, I. M. Thompson, S. M. Lippman, P. J. Goodman, D. Albanes, P. R. Taylor, C. Coltman

Research output: Contribution to journalArticlepeer-review

219 Scopus citations


Purpose: Growing evidence implies that selenium and vitamin E may decrease the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized prospective double-blind study designed to determine whether selenium and vitamin E decrease the risk of prostate cancer in healthy men. Materials and Methods: The preclinical and epidemiological evidence regarding chemoprevention with selenium and vitamin E were reviewed. Secondary analyses from randomized trials of the 2 agents were included in the current analysis. Data from these analyses as well as evidence from the Prostate Cancer Prevention Trial were used to develop the SELECT schema. Results: Preclinical, epidemiological and phase III data imply that selenium and vitamin E have potential efficacy for prostate cancer prevention. The experience of the Prostate Cancer Prevention Trial shows the interest and dedication of healthy men to long-term studies of cancer prevention. A total of 32,400 men are planned to be randomized in SELECT. Conclusions: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment in the study is planned to begin in 2001 with final results anticipated in 2013.

Original languageEnglish (US)
Pages (from-to)1311-1315
Number of pages5
JournalJournal of Urology
Issue number4
StatePublished - Jan 1 2001


  • Chemoprevention
  • Prostate
  • Prostatic neoplasms
  • Selenium
  • Vitamin E

ASJC Scopus subject areas

  • Urology


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