TY - GEN
T1 - Seizure onset zone localization from many invasive EEG channels using directed functional connectivity
AU - Van Mierlo, Pieter
AU - Coito, Ana
AU - Vulliémoz, Serge
AU - Lie, Octavian
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/11/28
Y1 - 2016/11/28
N2 - In this study we investigated how directed functional connectivity can be used to localize the seizure onset zone (SOZ) from ictal intracranial EEG (iEEG) recordings. First, simulations were conducted to investigate the performance of two directed functional connectivity measures, the Adaptive Directed Transfer Function (ADTF) and the Adaptive Partial Directed Coherence (APDC), in combinations with two graph measures, the out-degree and the shortest path, to localize the SOZ. Afterwards the method was applied to the seizure of an epileptic patient, recorded with 113-channel iEEG and localization was compared with the subsequent resection that rendered the patient seizure free. We found both in simulations and in the patient data that the ADTF combined with the out-degree and shortest path resulted in correct SOZ localization. We can conclude that ADTF combined with out-degree or shortest path are most optimal to localize the SOZ from a high number of iEEG channels.
AB - In this study we investigated how directed functional connectivity can be used to localize the seizure onset zone (SOZ) from ictal intracranial EEG (iEEG) recordings. First, simulations were conducted to investigate the performance of two directed functional connectivity measures, the Adaptive Directed Transfer Function (ADTF) and the Adaptive Partial Directed Coherence (APDC), in combinations with two graph measures, the out-degree and the shortest path, to localize the SOZ. Afterwards the method was applied to the seizure of an epileptic patient, recorded with 113-channel iEEG and localization was compared with the subsequent resection that rendered the patient seizure free. We found both in simulations and in the patient data that the ADTF combined with the out-degree and shortest path resulted in correct SOZ localization. We can conclude that ADTF combined with out-degree or shortest path are most optimal to localize the SOZ from a high number of iEEG channels.
KW - Directed functional connectivity
KW - Epilepsy
KW - Intracranial EEG
KW - Seizure onset zone localization
UR - http://www.scopus.com/inward/record.url?scp=85005963665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85005963665&partnerID=8YFLogxK
U2 - 10.1109/EUSIPCO.2016.7760249
DO - 10.1109/EUSIPCO.2016.7760249
M3 - Conference contribution
AN - SCOPUS:85005963665
T3 - European Signal Processing Conference
SP - 255
EP - 259
BT - 2016 24th European Signal Processing Conference, EUSIPCO 2016
PB - European Signal Processing Conference, EUSIPCO
T2 - 24th European Signal Processing Conference, EUSIPCO 2016
Y2 - 28 August 2016 through 2 September 2016
ER -