Secretion of salivary statherin is compromised in uncontrolled diabetic patients

Masahiro Izumi, Bin Xian Zhang, David D. Dean, Alan L. Lin, Michèle J. Saunders, Helen P. Hazuda, Chih Ko Yeh

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Statherin is an important salivary protein for maintaining oral health. The purpose of the current study was to determine if differences in statherin levels exist between diabetic and healthy subjects. Methods: A total of 48 diabetic and healthy controls were randomly selected from a community-based database. Diabetic subjects (n. = 24) had fasting glucose levels >. 180. mg/dL, while controls (n. = 24) had levels <. 110. mg/dL. Parotid saliva (PS) and sublingual/submandibular saliva (SS) were collected and salivary flow rates determined. Salivary statherin levels were determined by densitometry of Western blots. Blood hemoglobin A1c (HbA1c) and total protein in saliva were also obtained. Results: SS, but not PS, salivary flow rate and total protein in diabetics were significantly less than those in healthy controls (p. = 0.021 & p. <. 0.001 respectively). Correlation analysis revealed the existence of a negative correlation between PS statherin levels and HbA1c (p. = 0.012) and fasting glucose (p. = 0.021) levels, while no such correlation was found for SS statherin levels. When statherin levels were normalized to total salivary protein, the proportion of PS statherin, but not SS statherin, in diabetics was significantly less than that in controls (p. = 0.032). In contrast, the amount of statherin secretion in SS, but not PS, was significantly decreased in diabetics compared to controls (p. = 0.016). Conclusions and general significance: The results show that synthesis and secretion of statherin is reduced in diabetics and this reduction is salivary gland specific. As compromised salivary statherin secretion leads to increased oral health risk, this study indicates that routine oral health assessment of these patients is warranted.

Original languageEnglish (US)
Pages (from-to)135-140
Number of pages6
JournalBBA Clinical
StatePublished - Jun 1 2015


  • Diabetes
  • Oral health
  • Saliva
  • Statherin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Physiology (medical)


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