Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia

Cezary Chojnacki, Tomasz Poplawski, Grazyna Klupinska, Janusz Blasiak, Jan Chojnacki, Russel J. Reiter

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Aim: To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin (6-OHMS), in functional dyspepsia (FD). Methods: Ninety individuals were enrolled in the study: 30 in each study group: patients with postprandial distress syndrome (PDS), epigastric pain syndrome (EPS), and controls. Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed. Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay. Results: Serum melatonin concentration at night and in the morning was significantly (P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL, quartile range (QR): 79.8-116.2; at 09.00 h-14.3 pg/mL, QR: 7.06-19.0] than in EPS (57.2 pg/mL, QR: 42.6-73.1; 8.1 pg/mL, QR: 4.1-9.3) and control patients (57.7 pg/mL, QR: 51.2-62.5; 8.1 pg/mL, QR: 5.4-10.3). A similar relationship was observed for urinary 6-OHMS excretion. Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes, whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms. Conclusion: Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD.

Original languageEnglish (US)
Pages (from-to)2646-2651
Number of pages6
JournalWorld Journal of Gastroenterology
Issue number21
StatePublished - Jun 7 2011


  • 6-sulfatoxymelatonin
  • Epigastric pain syndrome
  • Functional dyspepsia
  • Melatonin
  • Postprandial distress syndrome

ASJC Scopus subject areas

  • Gastroenterology


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