Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia

Cezary Chojnacki, Tomasz Poplawski, Grazyna Klupinska, Janusz Blasiak, Jan Chojnacki, Russel J Reiter

Research output: Contribution to journalArticle

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Abstract

Aim: To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin (6-OHMS), in functional dyspepsia (FD). Methods: Ninety individuals were enrolled in the study: 30 in each study group: patients with postprandial distress syndrome (PDS), epigastric pain syndrome (EPS), and controls. Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed. Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay. Results: Serum melatonin concentration at night and in the morning was significantly (P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL, quartile range (QR): 79.8-116.2; at 09.00 h-14.3 pg/mL, QR: 7.06-19.0] than in EPS (57.2 pg/mL, QR: 42.6-73.1; 8.1 pg/mL, QR: 4.1-9.3) and control patients (57.7 pg/mL, QR: 51.2-62.5; 8.1 pg/mL, QR: 5.4-10.3). A similar relationship was observed for urinary 6-OHMS excretion. Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes, whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms. Conclusion: Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD.

Original languageEnglish (US)
Pages (from-to)2646-2651
Number of pages6
JournalWorld Journal of Gastroenterology
Volume17
Issue number21
DOIs
StatePublished - Jun 7 2011

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Dyspepsia
Melatonin
Pain
Serum
Urine Specimen Collection
6-sulfatoxymelatonin
Differential Diagnosis
Enzyme-Linked Immunosorbent Assay

Keywords

  • 6-sulfatoxymelatonin
  • Epigastric pain syndrome
  • Functional dyspepsia
  • Melatonin
  • Postprandial distress syndrome

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia. / Chojnacki, Cezary; Poplawski, Tomasz; Klupinska, Grazyna; Blasiak, Janusz; Chojnacki, Jan; Reiter, Russel J.

In: World Journal of Gastroenterology, Vol. 17, No. 21, 07.06.2011, p. 2646-2651.

Research output: Contribution to journalArticle

Chojnacki, Cezary ; Poplawski, Tomasz ; Klupinska, Grazyna ; Blasiak, Janusz ; Chojnacki, Jan ; Reiter, Russel J. / Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia. In: World Journal of Gastroenterology. 2011 ; Vol. 17, No. 21. pp. 2646-2651.
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abstract = "Aim: To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin (6-OHMS), in functional dyspepsia (FD). Methods: Ninety individuals were enrolled in the study: 30 in each study group: patients with postprandial distress syndrome (PDS), epigastric pain syndrome (EPS), and controls. Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed. Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay. Results: Serum melatonin concentration at night and in the morning was significantly (P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL, quartile range (QR): 79.8-116.2; at 09.00 h-14.3 pg/mL, QR: 7.06-19.0] than in EPS (57.2 pg/mL, QR: 42.6-73.1; 8.1 pg/mL, QR: 4.1-9.3) and control patients (57.7 pg/mL, QR: 51.2-62.5; 8.1 pg/mL, QR: 5.4-10.3). A similar relationship was observed for urinary 6-OHMS excretion. Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes, whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms. Conclusion: Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD.",
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AU - Blasiak, Janusz

AU - Chojnacki, Jan

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AB - Aim: To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin (6-OHMS), in functional dyspepsia (FD). Methods: Ninety individuals were enrolled in the study: 30 in each study group: patients with postprandial distress syndrome (PDS), epigastric pain syndrome (EPS), and controls. Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed. Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay. Results: Serum melatonin concentration at night and in the morning was significantly (P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL, quartile range (QR): 79.8-116.2; at 09.00 h-14.3 pg/mL, QR: 7.06-19.0] than in EPS (57.2 pg/mL, QR: 42.6-73.1; 8.1 pg/mL, QR: 4.1-9.3) and control patients (57.7 pg/mL, QR: 51.2-62.5; 8.1 pg/mL, QR: 5.4-10.3). A similar relationship was observed for urinary 6-OHMS excretion. Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes, whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms. Conclusion: Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD.

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KW - Postprandial distress syndrome

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