Secretin Provocation Test in the Diagnosis of Zollinger‐EIlison Syndrome

Charles E. Brady

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The secretin stimulation test has become the preferred provocative test in suspected cases of Zollinger‐Ellison syndrome. A pure secretin preparation, a gastrin‐specific radioimmunoassay, and an appropriate sampling sequence are important for the proper interpretation of this test. Gastric acid analysis is necessary in the assessment of hypergastrinemia to confirm acid hypersecretion and exclude achlorhydria. When properly performed and interpreted, the secretin provocation test offers a safe, expeditious, and reliable means of evaluating patients with hypergastrinemia.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalThe American Journal of Gastroenterology
Issue number2
StatePublished - Feb 1991

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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