Secondary chronic myelogenous leukemia: A diverse pathogenesis?

R. C.T. Aguiar, B. Beitler, P. E. Dorlhiac-Llacer, D. A.F. Chamone

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A patient with myasthenia gravis and a thymoma did not respond to thymectomy. He was submitted to radiotherapy concurrent with steroid therapy followed by an alkylating based chemotherapy. Four years later, he developed an otherwise typical Philadelphia chromosome/BCR-ABL positive chronic myelogenous leukemia (CML) that quickly evolved to a blast crisis. We discuss the possible cause-effect mechanism between the previous treatment and CML, and suggest that a distinct mechanism, albeit unknown, could be involved in the development and progression of secondary CML.

Original languageEnglish (US)
Pages (from-to)101-103
Number of pages3
JournalActa Haematologica
Issue number2
StatePublished - 1994
Externally publishedYes


  • Chronic myelogenous leukemia
  • Oncogene
  • Secondary leukemia
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Hematology


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