Secondary chemotherapy of advanced breast cancer

Ira S. Goldenberg, C. A. McMahan, George C. Escher, Herbert Volk, Fred J. Ansfield, Kenneth B. Olson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A randomized, protocol study by the Cooperative Breast Cancer Group has demonstrated the efficacy of chlorambucil, prednisone, hydrocortisone, and triiodothyronine as secondary therapy for advanced female breast cancer. Objective regression rates of 20.7% for chlorambucil and prednisone combined, 11.8% for hydrocortisone with triiodothyronine, and 9.8% for chlorambucil alone were defined. For the patient with advancing metastatic disease who has received initial hormonal therapy, it is recommended that further treatment with the combination of chlorambucil and prednisone be considered.

Original languageEnglish (US)
Pages (from-to)660-663
Number of pages4
Issue number3
StatePublished - Mar 1973
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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