Thirty-two second malignancies (21 acute leukemias and 11 solid tumors) were identified among 659 patients with all stages of Hodgkin's disease treated by members of the Southwest Oncology Group. There were no leukemias and one solid tumor among 95 patients treated with radiotherapy alone. The actuarial risk of developing acute leukemia at 7 years was 6.2% for chemotherapy alone, 6.4% for combined modality, and 7.7% for salvage chemotherapy. The incidence of acute leukemia was higher (P = 0.002) among those whose treatment began at ≥ 40 years of age. The actuarial in that group was 20.7% at 7 years. These data are compatible with the hypothesis that chemotherapy alone, combined modality, and salvage chemotherapy have an equivalent oncogenic potential and that patients ≥ 40 years of age have an enhanced susceptibility to these oncogenic stimuli.
|Original language||English (US)|
|Number of pages||11|
|Journal||Cancer Treatment Reports|
|State||Published - 1982|
ASJC Scopus subject areas
- Cancer Research