Searching for the immune basis of obsessive-compulsive disorder

Antonio Lucio Teixeira, David Henrique Rodrigues, Andrea Hovarth Marques, Eurípedes C. Miguel, Leonardo F. Fontenelle

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The etiopathogenesis of obsessive-compulsive disorder (OCD) remains elusive. Clinical observation of the elevated frequency of obsessive-compulsive symptoms in patients with rheumatic fever, a post-streptococcal autoimmune disease, prompted the study of immune parameters in OCD. Anti-basal ganglia antibodies have been described in a subset of OCD patients. The assessment of circulating cytokines and immune cells confirmed unequivocal changes in at least some patients, although it is difficult to establish a particular immune profile in OCD. Several factors, including the use of psychotropic drugs and the presence of comorbid conditions, seem to influence these immune parameters.

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalNeuroImmunoModulation
Volume21
Issue number2-3
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Anti-basal ganglia antibodies
  • Obsessive-compulsive disorder
  • Rheumatic chorea

ASJC Scopus subject areas

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems

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