Searching for the immune basis of obsessive-compulsive disorder

Antonio Lucio Teixeira; David Henrique Rodrigues; Andrea Hovarth Marques; Eurípedes C. Miguel; Leonardo F. Fontenelle

doi:10.1159/000356554

Searching for the immune basis of obsessive-compulsive disorder

Antonio Lucio Teixeira, David Henrique Rodrigues, Andrea Hovarth Marques, Eurípedes C. Miguel, Leonardo F. Fontenelle

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The etiopathogenesis of obsessive-compulsive disorder (OCD) remains elusive. Clinical observation of the elevated frequency of obsessive-compulsive symptoms in patients with rheumatic fever, a post-streptococcal autoimmune disease, prompted the study of immune parameters in OCD. Anti-basal ganglia antibodies have been described in a subset of OCD patients. The assessment of circulating cytokines and immune cells confirmed unequivocal changes in at least some patients, although it is difficult to establish a particular immune profile in OCD. Several factors, including the use of psychotropic drugs and the presence of comorbid conditions, seem to influence these immune parameters.

Original language	English (US)
Pages (from-to)	152-158
Number of pages	7
Journal	NeuroImmunoModulation
Volume	21
Issue number	2-3
DOIs	https://doi.org/10.1159/000356554
State	Published - 2014
Externally published	Yes

Keywords

Anti-basal ganglia antibodies
Obsessive-compulsive disorder
Rheumatic chorea

ASJC Scopus subject areas

Immunology
Endocrinology
Neurology
Endocrine and Autonomic Systems

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10.1159/000356554

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abstract = "The etiopathogenesis of obsessive-compulsive disorder (OCD) remains elusive. Clinical observation of the elevated frequency of obsessive-compulsive symptoms in patients with rheumatic fever, a post-streptococcal autoimmune disease, prompted the study of immune parameters in OCD. Anti-basal ganglia antibodies have been described in a subset of OCD patients. The assessment of circulating cytokines and immune cells confirmed unequivocal changes in at least some patients, although it is difficult to establish a particular immune profile in OCD. Several factors, including the use of psychotropic drugs and the presence of comorbid conditions, seem to influence these immune parameters.",

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Searching for the immune basis of obsessive-compulsive disorder

Abstract

Keywords

ASJC Scopus subject areas

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