Searching for the Genetic Determinants of Peripheral Arterial Disease: A Review of the Literature and Future Directions

Dean L Kellogg Jr, Susan Fisher-Hoch, Joseph B. McCormick, Anand Prasad

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Peripheral arterial disease (PAD) is a significant but under-recognized disease that is poorly understood despite population-scale genetic studies. To address this morbid disease, clinicians need additional tools to identify, prevent, and treat patients at risk for PAD. Genetic studies of coronary artery disease have yielded promising results for clinical application, which have thus far been lacking in PAD. In this article, we review recent findings, discuss limitations, and propose future directions of genomic study and clinical application. However, despite many studies, we still lack definitive genetic markers for PAD. This can be attributed to the heterogeneity of PAD's pathogenesis and clinical manifestations, as well as inconsistencies in study methodologies, limitations of current genetic assessment techniques, incompletely comprehended molecular pathophysiology, and confounding generalized atherosclerotic risk factors. The goals of this review are to evaluate the limitations of our current genetic knowledge of PAD and to propose approaches to expedite the identification of valuable markers of PAD.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalCardiology in review
Volume27
Issue number3
DOIs
StatePublished - May 1 2019

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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