Sealing of the follicular lumen of the anterior pituitary gland of the male rat

Y. Mabuchi, H. Maruyama, T. Yashiro, S. Tanida, C. Kurono, N. Honda, H. Kato, D. C. Herbert

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


It is commonly accepted that follicular lumina of the adult rat anterior pituitary gland are tightly sealed by junctional complexes, especially tight junctions. In this report, we describe the presence of follicular lumina that are unsealed. Peroxidase (HRP) was used to study such structures and when injected through the femoral vein, was observed in association with a few follicular lumina, on their microvilli and around the cilia of folliculo-stellate cells. The existence of peroxidase-positive follicles clearly shows that follicles of the hypophysis are not always firmly sealed by tight junctions. The folliculo-stellate cells which faced the peroxidase-positive follicles displayed HRP deposits which were membrane bound within their cytoplasm. These findings suggest an absorptive function for the folliculo-stellate cells.

Original languageEnglish (US)
Pages (from-to)631-635
Number of pages5
JournalTissue and Cell
Issue number6
StatePublished - 1996


  • Anterior pituitary gland
  • Follicular lumen
  • Folliculo-stellate cells
  • Peroxidase
  • Rat
  • Tight junctions

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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