Scopulariopsis, a poorly known opportunistic fungus: Spectrum of species in clinical samples and in vitro responses to antifungal drugs

Marcelo Sandoval-Denis, Deanna A. Sutton, Annette W. Fothergill, Josep Cano-Lira, Josepa Gené, C. A. Decock, G. S. De Hoog, Josep Guarro

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Ninety-nine isolates of clinical origin, tentatively identified as Scopulariopsis or Microascus, were morphologically and molecularly characterized by a combined analysis of the D1/D2 domains of the 28S rRNA gene and a fragment of the elongation factor 1- gene (EF1-) sequences. The most prevalent species was Scopulariopsis brevicaulis (49.4%), followed by Scopulariopsis gracilis (14.4%), Scopulariopsis brumptii (7.2%), Microascus cinereus (5.2%), the Scopulariopsis candida species complex (3.1%), and Microascus cirrosus (2.1%). The most common anatomic sites of isolation were the respiratory tract (61.6%), superficial tissue (19.2%), and deep tissue or fluid samples (19.2%). The antifungal susceptibilities of the isolates to eight drugs were tested in vitro, with all the drugs generally showing poor activity.

Original languageEnglish (US)
Pages (from-to)3937-3943
Number of pages7
JournalJournal of clinical microbiology
Volume51
Issue number12
DOIs
StatePublished - Dec 2013

ASJC Scopus subject areas

  • Microbiology (medical)

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