Scopolamine produces locomotor stereotypy in an open field but apomorphine does not

Kathyrne Mueller, Jennifer L. Peel

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Both dopaminergic and nondopaminergic drugs produce hyperlocomotion in rats. Dopaminergic drugs also produce focused stereotypy (absence of locomotion and intense sniffing or licking/biting of a restricted area of the environment). Some drugs produce repetitive routes of locomotion; this phenomenon might represent a combination of hyperlocomotion and stereotypy. Scopolamine (an acetylcholine antagonist) and apomorphine (a dopamine agonist) both produce hyperlocomotion in rats; apomorphine also produces focused stereotypy but scopolamine does not. This research determines whether these drugs also produce locomotor stereotypy as measured by γ. Scopolamine (0.5 and 2.0 mg/kg) produced locomotor stereotypy at both doses. Apomorphine (1.0, 2.0, and 3.0 mg/kg) failed to reliably produce locomotor stereotypy. Thus, there is not necessarily a relationship between the ability of a drug to produce focused stereotypy and the ability of the drug to produce locomotor stereotypy.

Original languageEnglish (US)
Pages (from-to)613-617
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume36
Issue number3
DOIs
StatePublished - Jul 1990
Externally publishedYes

Keywords

  • Apomorphine
  • Locomotor behavior
  • Locomotor stereotypy
  • Open field
  • Scopolamine

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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