Schistosomiasis induced-changes in glutathione levels and glutathione reductase/glutathione S-transferase activities in human liver

S. A. Sheweita, S. L. Habib, M. H. Mostafa

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Hepatosplenic schistosomiasis is a parasitic liver disease resulting in granuloma formation followed by liver fibrosis. The hepatic levels of reduced glutathione, and the activities of glutathione reductase and glutathione S-transferase in the liver of fifteen schistosome-infected patients compared with those of five liver schistosome-free samples were determined. The hepatic levels of reduced glutathione and glutathione reductase activity increased by 267 and 72%, respectively. Glutathione S-transferase activity decreased by 51% in the liver samples of schistosome-infected patients. The activities of alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase increased by 82, 74 and 100%, respectively. It seems that Schistosoma mansonichanges the hepatic levels of glutathione and the activities of glutathione-metabolizing enzymes. These alterations may change the capacity of the liver to detoxify and/or neutralize the toxic effects of either endogenous or exogenous compounds to which humans are exposed.

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalBiomedical Letters
Volume56
Issue number222
StatePublished - Dec 1 1997
Externally publishedYes

Keywords

  • Glutathione
  • Glutathione S-transferase
  • Schistosomiasis
  • Serum aminotransferases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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