Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors

Sixteen new members and a novel subfamily

Wenjie Wu, Edward G. Niles, Najib El-Sayed, Matthew Berriman, Philip T Loverde

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Nuclear receptors (NRs) are important transcriptional modulators in metazoans. Sixteen new NRs were identified in the Platyhelminth trematode, Schistosoma mansoni. Three were found to possess novel tandem DNA-binding domains that identify a new subfamily of NR. Two NRs are homologues of the thyroid hormone receptor that previously were thought to be restricted to chordates. This study brings the total number of identified NR in S. mansoni to 21. Phylogenetic and comparative genomic analyses demonstrate that S. mansoni NRs share an evolutionary lineage with that of arthropods and vertebrates. Phylogenic analysis shows that more than half of the S. mansoni nuclear receptors evolved from a second gene duplication. As the second gene duplication of NRs was thought to be specific to vertebrates, our data challenge the current theory of NR evolution.

Original languageEnglish (US)
Pages (from-to)303-315
Number of pages13
JournalGene
Volume366
Issue number2
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

Fingerprint

Trematoda
Schistosoma mansoni
Cytoplasmic and Nuclear Receptors
Gene Duplication
Vertebrates
Platyhelminths
Chordata
Thyroid Hormone Receptors
Arthropods

Keywords

  • Nuclear receptors
  • Schistosoma mansoni

ASJC Scopus subject areas

  • Genetics

Cite this

Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors : Sixteen new members and a novel subfamily. / Wu, Wenjie; Niles, Edward G.; El-Sayed, Najib; Berriman, Matthew; Loverde, Philip T.

In: Gene, Vol. 366, No. 2, 01.02.2006, p. 303-315.

Research output: Contribution to journalArticle

Wu, Wenjie ; Niles, Edward G. ; El-Sayed, Najib ; Berriman, Matthew ; Loverde, Philip T. / Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors : Sixteen new members and a novel subfamily. In: Gene. 2006 ; Vol. 366, No. 2. pp. 303-315.
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