Schistosoma mansoni genome: Closing in on a final gene set

Brian J. Haas, Matthew Berriman, Hirohisa Hirai, Gustavo G. Cerqueira, Philip T. LoVerde, Najib M. El-Sayed

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The Schistosoma mansoni genome sequencing consortium has recently released the latest versions of the genome assembly as well as an automated preliminary gene structure annotation. The combined datasets constitute a vast resource for researchers to exploit in a variety of post-genomic studies with an emphasis of transcriptomic and proteomic tools. Here we present an innovative method used for combining diverse sources of evidence including ab initio gene predictions, protein and transcript sequence homologies, and cross-genome sequence homologies between S. mansoni and Schistosoma japonicum to define a comprehensive list of protein-coding genes.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalExperimental Parasitology
Volume117
Issue number3
DOIs
StatePublished - Nov 1 2007

Keywords

  • Annotation
  • Gene finding
  • Genome
  • Schistosoma mansoni

ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases

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    Haas, B. J., Berriman, M., Hirai, H., Cerqueira, G. G., LoVerde, P. T., & El-Sayed, N. M. (2007). Schistosoma mansoni genome: Closing in on a final gene set. Experimental Parasitology, 117(3), 225-228. https://doi.org/10.1016/j.exppara.2007.06.005