Scheduling of vincristine: drug accumulation and response of xenografts of childhood rhabdomyosarcoma determined by frequency of administration.

J. A. Houghton, W. H. Meyer, Peter J Houghton

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Vincristine (VCR) is an effective agent in the treatment of childhood rhabdomyosarcoma. Clinically, schedules differ in frequency of administration. To determine the influence of administration frequency, accumulation of VCR in xenografts of human rhabdomyosarcoma has been evaluated following administration of drug at 7- or 21-day intervals. Accumulation was estimated from initial uptake, retention of unchanged drug in tumor tissues, tumor sensitivity, and growth rate. Data suggested that scheduling VCR every 7 days would be more effective than every 21 days, due to more rapid accumulation to cytotoxic levels. The effect of scheduling was examined in two rhabdomyosarcoma xenografts, where in vivo responses were similar to those predicted based upon drug uptake, retention, and growth characteristics for the tumors. Scheduling VCR at 7-day intervals was clearly superior to administration at 21-day intervals in these models.

Original languageEnglish (US)
Pages (from-to)717-721
Number of pages5
JournalCancer Treatment Reports
Volume71
Issue number7-8
StatePublished - Jul 1 1987
Externally publishedYes

Fingerprint

Rhabdomyosarcoma
Vincristine
Heterografts
Pharmaceutical Preparations
Neoplasms
Growth
Appointments and Schedules

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Scheduling of vincristine : drug accumulation and response of xenografts of childhood rhabdomyosarcoma determined by frequency of administration. / Houghton, J. A.; Meyer, W. H.; Houghton, Peter J.

In: Cancer Treatment Reports, Vol. 71, No. 7-8, 01.07.1987, p. 717-721.

Research output: Contribution to journalArticle

@article{6578e7ef59d440c6ab188050f25c7d31,
title = "Scheduling of vincristine: drug accumulation and response of xenografts of childhood rhabdomyosarcoma determined by frequency of administration.",
abstract = "Vincristine (VCR) is an effective agent in the treatment of childhood rhabdomyosarcoma. Clinically, schedules differ in frequency of administration. To determine the influence of administration frequency, accumulation of VCR in xenografts of human rhabdomyosarcoma has been evaluated following administration of drug at 7- or 21-day intervals. Accumulation was estimated from initial uptake, retention of unchanged drug in tumor tissues, tumor sensitivity, and growth rate. Data suggested that scheduling VCR every 7 days would be more effective than every 21 days, due to more rapid accumulation to cytotoxic levels. The effect of scheduling was examined in two rhabdomyosarcoma xenografts, where in vivo responses were similar to those predicted based upon drug uptake, retention, and growth characteristics for the tumors. Scheduling VCR at 7-day intervals was clearly superior to administration at 21-day intervals in these models.",
author = "Houghton, {J. A.} and Meyer, {W. H.} and Houghton, {Peter J}",
year = "1987",
month = "7",
day = "1",
language = "English (US)",
volume = "71",
pages = "717--721",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "7-8",

}

TY - JOUR

T1 - Scheduling of vincristine

T2 - drug accumulation and response of xenografts of childhood rhabdomyosarcoma determined by frequency of administration.

AU - Houghton, J. A.

AU - Meyer, W. H.

AU - Houghton, Peter J

PY - 1987/7/1

Y1 - 1987/7/1

N2 - Vincristine (VCR) is an effective agent in the treatment of childhood rhabdomyosarcoma. Clinically, schedules differ in frequency of administration. To determine the influence of administration frequency, accumulation of VCR in xenografts of human rhabdomyosarcoma has been evaluated following administration of drug at 7- or 21-day intervals. Accumulation was estimated from initial uptake, retention of unchanged drug in tumor tissues, tumor sensitivity, and growth rate. Data suggested that scheduling VCR every 7 days would be more effective than every 21 days, due to more rapid accumulation to cytotoxic levels. The effect of scheduling was examined in two rhabdomyosarcoma xenografts, where in vivo responses were similar to those predicted based upon drug uptake, retention, and growth characteristics for the tumors. Scheduling VCR at 7-day intervals was clearly superior to administration at 21-day intervals in these models.

AB - Vincristine (VCR) is an effective agent in the treatment of childhood rhabdomyosarcoma. Clinically, schedules differ in frequency of administration. To determine the influence of administration frequency, accumulation of VCR in xenografts of human rhabdomyosarcoma has been evaluated following administration of drug at 7- or 21-day intervals. Accumulation was estimated from initial uptake, retention of unchanged drug in tumor tissues, tumor sensitivity, and growth rate. Data suggested that scheduling VCR every 7 days would be more effective than every 21 days, due to more rapid accumulation to cytotoxic levels. The effect of scheduling was examined in two rhabdomyosarcoma xenografts, where in vivo responses were similar to those predicted based upon drug uptake, retention, and growth characteristics for the tumors. Scheduling VCR at 7-day intervals was clearly superior to administration at 21-day intervals in these models.

UR - http://www.scopus.com/inward/record.url?scp=0023371142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023371142&partnerID=8YFLogxK

M3 - Article

C2 - 3607783

AN - SCOPUS:0023371142

VL - 71

SP - 717

EP - 721

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 7-8

ER -