Abstract
Ramichloridium obovoideum ('Ramichloridium makenziei') is a rare cause of lethal cerebral phaeohyphomycosis. It has been, so far, geographically restricted to the Middle East. BALB/c mice were inoculated with two strains of R. obovoideum intracranially. Therapy with amphotericin B, itraconazole, or the investigationaI triazole SCH 56592 was conducted for 10 days. Half the mice were monitored for survival and half were killed for determination of the fungal load in brain tissue. Recipients of SCH 56592 had significantly prolonged survival and lower brain fungal burden, and this result was found for mice infected with both of the fungal strains tested. Itraconazole reduced the brain fungal load in mice infected with one strain but not the other, while amphotericin B had no effect on brain fungal concentrations. This study indicates a possible role of SCH 56592 in the treatment of the serious cerebral phaeohyphomycosis due to R. obovoideum.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1159-1162 |
| Number of pages | 4 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 44 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2000 |
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ASJC Scopus subject areas
- Pharmacology (medical)
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SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ('Ramichloridium mackenziei'). / Al-Abdely, Hail M.; Najvar, Laura; Bocanegra, Rosie; Fothergill, Annette; Loebenberg, David; Rinaldi, Michael G.; Graybill, John R.
In: Antimicrobial Agents and Chemotherapy, Vol. 44, No. 5, 05.2000, p. 1159-1162.Research output: Contribution to journal › Article
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TY - JOUR
T1 - SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ('Ramichloridium mackenziei')
AU - Al-Abdely, Hail M.
AU - Najvar, Laura
AU - Bocanegra, Rosie
AU - Fothergill, Annette
AU - Loebenberg, David
AU - Rinaldi, Michael G.
AU - Graybill, John R.
PY - 2000/5
Y1 - 2000/5
N2 - Ramichloridium obovoideum ('Ramichloridium makenziei') is a rare cause of lethal cerebral phaeohyphomycosis. It has been, so far, geographically restricted to the Middle East. BALB/c mice were inoculated with two strains of R. obovoideum intracranially. Therapy with amphotericin B, itraconazole, or the investigationaI triazole SCH 56592 was conducted for 10 days. Half the mice were monitored for survival and half were killed for determination of the fungal load in brain tissue. Recipients of SCH 56592 had significantly prolonged survival and lower brain fungal burden, and this result was found for mice infected with both of the fungal strains tested. Itraconazole reduced the brain fungal load in mice infected with one strain but not the other, while amphotericin B had no effect on brain fungal concentrations. This study indicates a possible role of SCH 56592 in the treatment of the serious cerebral phaeohyphomycosis due to R. obovoideum.
AB - Ramichloridium obovoideum ('Ramichloridium makenziei') is a rare cause of lethal cerebral phaeohyphomycosis. It has been, so far, geographically restricted to the Middle East. BALB/c mice were inoculated with two strains of R. obovoideum intracranially. Therapy with amphotericin B, itraconazole, or the investigationaI triazole SCH 56592 was conducted for 10 days. Half the mice were monitored for survival and half were killed for determination of the fungal load in brain tissue. Recipients of SCH 56592 had significantly prolonged survival and lower brain fungal burden, and this result was found for mice infected with both of the fungal strains tested. Itraconazole reduced the brain fungal load in mice infected with one strain but not the other, while amphotericin B had no effect on brain fungal concentrations. This study indicates a possible role of SCH 56592 in the treatment of the serious cerebral phaeohyphomycosis due to R. obovoideum.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034090743&partnerID=8YFLogxK
U2 - 10.1128/AAC.44.5.1159-1162.2000
DO - 10.1128/AAC.44.5.1159-1162.2000
M3 - Article
C2 - 10770745
AN - SCOPUS:0034090743
VL - 44
SP - 1159
EP - 1162
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 5
ER -