SCH 56592, amphotericin B, or itraconazole therapy of experimental murine cerebral phaeohyphomycosis due to Ramichloridium obovoideum ('Ramichloridium mackenziei')

Hail M. Al-Abdely, Laura Najvar, Rosie Bocanegra, Annette Fothergill, David Loebenberg, Michael G. Rinaldi, John R. Graybill

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Ramichloridium obovoideum ('Ramichloridium makenziei') is a rare cause of lethal cerebral phaeohyphomycosis. It has been, so far, geographically restricted to the Middle East. BALB/c mice were inoculated with two strains of R. obovoideum intracranially. Therapy with amphotericin B, itraconazole, or the investigationaI triazole SCH 56592 was conducted for 10 days. Half the mice were monitored for survival and half were killed for determination of the fungal load in brain tissue. Recipients of SCH 56592 had significantly prolonged survival and lower brain fungal burden, and this result was found for mice infected with both of the fungal strains tested. Itraconazole reduced the brain fungal load in mice infected with one strain but not the other, while amphotericin B had no effect on brain fungal concentrations. This study indicates a possible role of SCH 56592 in the treatment of the serious cerebral phaeohyphomycosis due to R. obovoideum.

Original languageEnglish (US)
Pages (from-to)1159-1162
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume44
Issue number5
DOIs
StatePublished - May 2000

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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