Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: Successful combination therapy with voriconazole and terbinafine

Sunil V. Bhat, David L. Paterson, Michael G. Rinaldi, Peter J. Veldkamp

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

A patient with chronic granulomatous disease developed brain abscesses with Scedosporium prolificans. In vitro susceptibility revealed a synergistic effect of terbinafine and voriconazole. He received therapy with both these antifungals which resulted in disappearance of the brain abscesses. This is the first reported cure of a CNS S. prolificans infection in an immunocompromised host.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalScandinavian Journal of Infectious Diseases
Volume39
Issue number1
DOIs
StatePublished - 2007

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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