Scedosporium apiospermum soft tissue infection successfully treated with voriconazole: Potential pitfalls in the transition from intravenous to oral therapy

Joanna M. Schaenman, Daniel B. DiGiulio, Laurence F. Mirels, Nancy M. McClenny, Gerald J. Berry, Annette W. Fothergill, Michael G. Rinaldi, Jose G. Montoya

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36 Scopus citations

Abstract

An immunocompromised patient with an invasive soft tissue infection due to Scedosporium apiospermum was successfully treated with voriconazole and surgical debridement. After transition from intravenous to oral therapy, successive adjustments of the oral dose were required to achieve complete resolution. For soft tissue infections due to molds characterized by thin, septate hyphae branching at acute angles, voriconazole should be considered a first-line antifungal agent. The potential usefulness of plasma voriconazole levels for guiding optimal therapy should be investigated.

Original languageEnglish (US)
Pages (from-to)973-977
Number of pages5
JournalJournal of clinical microbiology
Volume43
Issue number2
DOIs
StatePublished - Feb 1 2005

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ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Schaenman, J. M., DiGiulio, D. B., Mirels, L. F., McClenny, N. M., Berry, G. J., Fothergill, A. W., Rinaldi, M. G., & Montoya, J. G. (2005). Scedosporium apiospermum soft tissue infection successfully treated with voriconazole: Potential pitfalls in the transition from intravenous to oral therapy. Journal of clinical microbiology, 43(2), 973-977. https://doi.org/10.1128/JCM.43.2.973-977.2005