TY - JOUR
T1 - Sarcoidosis after treatment with interferon-α
T2 - A case series and review of the literature
AU - Goldberg, Hilary J.
AU - Fiedler, Douglas
AU - Webb, Amy
AU - Jagirdar, Jaishree
AU - Hoyumpa, Anastacio M.
AU - Peters, Jay
PY - 2006/11
Y1 - 2006/11
N2 - Recombinant interferon-α (rINF-α) is an immunomodulator used in the treatment of various conditions, including viral infections and malignancies. The use of rINF-α has been associated with the development of sarcoidosis in recent case reports. In this series, we report the incidence of sarcoidosis in recipients of rINF-α for hepatitis C viral (HCV) infection at our institution. We also review the 57 additional cases of sarcoidosis associated with rINF-α described in the literature, including clinical presentation, radiographic findings, management, and outcomes, and discuss the potential mechanisms by which rINF-α may lead to the development of sarcoidosis.
AB - Recombinant interferon-α (rINF-α) is an immunomodulator used in the treatment of various conditions, including viral infections and malignancies. The use of rINF-α has been associated with the development of sarcoidosis in recent case reports. In this series, we report the incidence of sarcoidosis in recipients of rINF-α for hepatitis C viral (HCV) infection at our institution. We also review the 57 additional cases of sarcoidosis associated with rINF-α described in the literature, including clinical presentation, radiographic findings, management, and outcomes, and discuss the potential mechanisms by which rINF-α may lead to the development of sarcoidosis.
KW - Hepatitis
KW - Interferon
KW - Sarcoid
UR - https://www.scopus.com/pages/publications/33749491825
UR - https://www.scopus.com/pages/publications/33749491825#tab=citedBy
U2 - 10.1016/j.rmed.2006.03.004
DO - 10.1016/j.rmed.2006.03.004
M3 - Article
C2 - 16675213
AN - SCOPUS:33749491825
SN - 0954-6111
VL - 100
SP - 2063
EP - 2068
JO - Respiratory Medicine
JF - Respiratory Medicine
IS - 11
ER -