Sarcoidosis after treatment with interferon-α: A case series and review of the literature

Hilary J. Goldberg, Douglas Fiedler, Amy Webb, Jashiree Jagirdar, Anastacio M. Hoyumpa, Jay Peters

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Abstract

Recombinant interferon-α (rINF-α) is an immunomodulator used in the treatment of various conditions, including viral infections and malignancies. The use of rINF-α has been associated with the development of sarcoidosis in recent case reports. In this series, we report the incidence of sarcoidosis in recipients of rINF-α for hepatitis C viral (HCV) infection at our institution. We also review the 57 additional cases of sarcoidosis associated with rINF-α described in the literature, including clinical presentation, radiographic findings, management, and outcomes, and discuss the potential mechanisms by which rINF-α may lead to the development of sarcoidosis.

Original languageEnglish (US)
Pages (from-to)2063-2068
Number of pages6
JournalRespiratory Medicine
Volume100
Issue number11
DOIs
Publication statusPublished - Nov 1 2006

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Keywords

  • Hepatitis
  • Interferon
  • Sarcoid

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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