Sarcoidosis after treatment with interferon-α: A case series and review of the literature

Hilary J. Goldberg; Douglas Fiedler; Amy Webb; Jaishree Jagirdar; Anastacio M. Hoyumpa; Jay Peters

doi:10.1016/j.rmed.2006.03.004

Sarcoidosis after treatment with interferon-α: A case series and review of the literature

Hilary J. Goldberg, Douglas Fiedler, Amy Webb, Jaishree Jagirdar, Anastacio M. Hoyumpa, Jay Peters

Department of Medicine

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Recombinant interferon-α (rINF-α) is an immunomodulator used in the treatment of various conditions, including viral infections and malignancies. The use of rINF-α has been associated with the development of sarcoidosis in recent case reports. In this series, we report the incidence of sarcoidosis in recipients of rINF-α for hepatitis C viral (HCV) infection at our institution. We also review the 57 additional cases of sarcoidosis associated with rINF-α described in the literature, including clinical presentation, radiographic findings, management, and outcomes, and discuss the potential mechanisms by which rINF-α may lead to the development of sarcoidosis.

Original language	English (US)
Pages (from-to)	2063-2068
Number of pages	6
Journal	Respiratory Medicine
Volume	100
Issue number	11
DOIs	https://doi.org/10.1016/j.rmed.2006.03.004
State	Published - Nov 2006

Keywords

Hepatitis
Interferon
Sarcoid

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.rmed.2006.03.004

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abstract = "Recombinant interferon-α (rINF-α) is an immunomodulator used in the treatment of various conditions, including viral infections and malignancies. The use of rINF-α has been associated with the development of sarcoidosis in recent case reports. In this series, we report the incidence of sarcoidosis in recipients of rINF-α for hepatitis C viral (HCV) infection at our institution. We also review the 57 additional cases of sarcoidosis associated with rINF-α described in the literature, including clinical presentation, radiographic findings, management, and outcomes, and discuss the potential mechanisms by which rINF-α may lead to the development of sarcoidosis.",

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AU - Fiedler, Douglas

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AU - Jagirdar, Jaishree

AU - Hoyumpa, Anastacio M.

AU - Peters, Jay

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Sarcoidosis after treatment with interferon-α: A case series and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

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