Sarcoidosis after treatment with interferon-α: A case series and review of the literature

Hilary J. Goldberg, Douglas Fiedler, Amy Webb, Jaishree Jagirdar, Anastacio M. Hoyumpa, Jay Peters

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Recombinant interferon-α (rINF-α) is an immunomodulator used in the treatment of various conditions, including viral infections and malignancies. The use of rINF-α has been associated with the development of sarcoidosis in recent case reports. In this series, we report the incidence of sarcoidosis in recipients of rINF-α for hepatitis C viral (HCV) infection at our institution. We also review the 57 additional cases of sarcoidosis associated with rINF-α described in the literature, including clinical presentation, radiographic findings, management, and outcomes, and discuss the potential mechanisms by which rINF-α may lead to the development of sarcoidosis.

Original languageEnglish (US)
Pages (from-to)2063-2068
Number of pages6
JournalRespiratory Medicine
Issue number11
StatePublished - Nov 2006


  • Hepatitis
  • Interferon
  • Sarcoid

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Sarcoidosis after treatment with interferon-α: A case series and review of the literature'. Together they form a unique fingerprint.

Cite this