Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets

Dorthea Johnson-Alvares, Germaine Cornélissen, Ana Portela, Erna Halberg, Joel D. Rudney, Chih Ko Yeh, Michael Dodds, Erhard Haus, Erwin Schaffer, Mikhail Blank, Franz Halberg

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1 Scopus citations

Abstract

Background. Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies. Materials and methods. CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation. Results. CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work. Conclusions. Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalIn Vivo
Volume16
Issue number1
Publication statusPublished - May 6 2002

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Keywords

  • CA130
  • Diet
  • Parotid denervation
  • Rat
  • Saliva

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Johnson-Alvares, D., Cornélissen, G., Portela, A., Halberg, E., Rudney, J. D., Yeh, C. K., ... Halberg, F. (2002). Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets. In Vivo, 16(1), 25-28.