Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics.

Monice M. Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel Liebler, James G. Marks, Ronald C. Shank, Thomas J Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Stearyl heptanoate is an ester of stearyl alcohol and heptanoic acid that functions in cosmetics as a skin conditioning agent and is in the general class of chemicals called stearyl alkanoates. Stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are stearyl alkanoates with similar chemical structures, toxicokinetics, and functions in cosmetics. These water-insoluble stearyl alkanoates, when metabolized, yield stearyl alcohol and a corresponding fatty acid. The available information supports the safety of all of the related stearyl alkanoates. The Expert Panel concluded that stearyl heptanoate, stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are safe in the present practices of use and concentration.

Original languageEnglish (US)
JournalInternational Journal of Toxicology
Volume31
Issue number5 Suppl
StatePublished - Sep 2012
Externally publishedYes

Fingerprint

Caprylates
Cosmetics
Heptanoic Acids
Safety
Skin
Esters
Fatty Acids
Water
stearyl stearate
stearyl heptanoate
stearyl alcohol
octadecyl palmitate

ASJC Scopus subject areas

  • Toxicology

Cite this

Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... Andersen, F. A. (2012). Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics. International Journal of Toxicology, 31(5 Suppl).

Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics. / Fiume, Monice M.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J; Snyder, Paul W.; Andersen, F. Alan.

In: International Journal of Toxicology, Vol. 31, No. 5 Suppl, 09.2012.

Research output: Contribution to journalArticle

Fiume, MM, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, D, Marks, JG, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2012, 'Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics.', International Journal of Toxicology, vol. 31, no. 5 Suppl.
Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D et al. Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics. International Journal of Toxicology. 2012 Sep;31(5 Suppl).
Fiume, Monice M. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J ; Snyder, Paul W. ; Andersen, F. Alan. / Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics. In: International Journal of Toxicology. 2012 ; Vol. 31, No. 5 Suppl.
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