Safety Assessment of Stearyl Heptanoate and Related Stearyl Alkanoates as Used in Cosmetics

Monice M. Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

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Abstract

Stearyl heptanoate is an ester of stearyl alcohol and heptanoic acid that functions in cosmetics as a skin conditioning agent and is in the general class of chemicals called stearyl alkanoates. Stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are stearyl alkanoates with similar chemical structures, toxicokinetics, and functions in cosmetics. These water-insoluble stearyl alkanoates, when metabolized, yield stearyl alcohol and a corresponding fatty acid. The available information supports the safety of all of the related stearyl alkanoates. The Expert Panel concluded that stearyl heptanoate, stearyl caprylate, stearyl palmitate, stearyl stearate, stearyl behenate, and stearyl olivate are safe in the present practices of use and concentration.

Original languageEnglish (US)
Pages (from-to)141S-146S
JournalInternational journal of toxicology
Volume31
DOIs
StatePublished - Sep 2012
Externally publishedYes

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Keywords

  • stearyl heptanoate

ASJC Scopus subject areas

  • Toxicology

Cite this

Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., & Andersen, F. A. (2012). Safety Assessment of Stearyl Heptanoate and Related Stearyl Alkanoates as Used in Cosmetics. International journal of toxicology, 31, 141S-146S. https://doi.org/10.1177/1091581812460408