Safety assessment of silylates and surface-modified siloxysilicates.

Lillian C. Becker, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Thomas J Slaga, F. Alan Andersen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate as used in cosmetics. These silylates and surface-modified siloxysilicates function in cosmetics as antifoaming agents, anticaking agents, bulking agents, binders, skin-conditioning agents--emollient, skin-conditioning agents-occlusive, slip modifiers, suspension agents--nonsurfactant, and viscosity increasing agents--nonaqueous. The Expert Panel reviewed the available animal and clinical data as well as information from a previous CIR safety assessment of amorphous silica. The CIR Expert Panel concluded that silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate are safe as used when formulated and delivered in the final product not to be irritating or sensitizing to the respiratory tract.

Original languageEnglish (US)
JournalInternational Journal of Toxicology
Volume32
Issue number3 Suppl
StatePublished - May 2013
Externally publishedYes

Fingerprint

Cosmetics
Silicon Dioxide
Safety
Antifoaming Agents
Emollients
Skin
Viscosity
Respiratory System
Suspensions
Binders
Animals

ASJC Scopus subject areas

  • Toxicology
  • Medicine(all)

Cite this

Becker, L. C., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... Andersen, F. A. (2013). Safety assessment of silylates and surface-modified siloxysilicates. International Journal of Toxicology, 32(3 Suppl).

Safety assessment of silylates and surface-modified siloxysilicates. / Becker, Lillian C.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Slaga, Thomas J; Andersen, F. Alan.

In: International Journal of Toxicology, Vol. 32, No. 3 Suppl, 05.2013.

Research output: Contribution to journalArticle

Becker, LC, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, D, Marks, JG, Shank, RC, Slaga, TJ, Slaga, TJ & Andersen, FA 2013, 'Safety assessment of silylates and surface-modified siloxysilicates.', International Journal of Toxicology, vol. 32, no. 3 Suppl.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D et al. Safety assessment of silylates and surface-modified siloxysilicates. International Journal of Toxicology. 2013 May;32(3 Suppl).
Becker, Lillian C. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J. ; Slaga, Thomas J ; Andersen, F. Alan. / Safety assessment of silylates and surface-modified siloxysilicates. In: International Journal of Toxicology. 2013 ; Vol. 32, No. 3 Suppl.
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