Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics

Monice M. Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Propylene glycol is an aliphatic alcohol that functions as a skin conditioning agent, viscosity decreasing agent, solvent, and fragrance ingredient in cosmetics. Tripropylene glycol functions as a humectant, antioxidant, and emulsion stabilizer. Polypropylene glycols (PPGs), including PPG-3, PPG-7, PPG-9, PPG-12, PPG-13, PPG-15, PPG-16, PPG-17, PPG-20, PPG-26, PPG-30, PPG-33, PPG-34, PPG-51, PPG-52, and PPG-69, function primarily as skin conditioning agents, with some solvent use. The majority of the safety and toxicity information presented is for propylene glycol (PG). Propylene glycol is generally nontoxic and is noncarcinogenic. Clinical studies demonstrated an absence of dermal sensitization at use concentrations, although concerns about irritation remained. The CIR Expert Panel determined that the available information support the safety of tripropylene glycol as well as all the PPGs. The Expert Panel concluded that PG, tripropylene glycol, and PPGs ≥3 are safe as used in cosmetic formulations when formulated to be nonirritating.

Original languageEnglish (US)
Pages (from-to)245S-260S
JournalInternational journal of toxicology
Volume31
DOIs
StatePublished - Sep 2012
Externally publishedYes

Keywords

  • PPGs
  • propylene glycol
  • tripropylene glycol

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics'. Together they form a unique fingerprint.

Cite this