Safety Assessment of Polyaminopropyl Biguanide (Polyhexamethylene Biguanide Hydrochloride) as Used in Cosmetics

Wilbur Johnson, Ivan Boyer, Jinqiu Zhu, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth

Research output: Contribution to journalArticlepeer-review

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Polyaminopropyl Biguanide (polyhexamethylene biguanide hydrochloride), which functions as a preservative in cosmetic products. The Panel reviewed relevant data relating to the safety of this ingredient and concluded that Polyaminopropyl Biguanide is safe in cosmetics in the present practices of use and concentration described in the safety assessment, when formulated to be nonirritating and nonsensitizing, which may be based on a quantitative risk assessment or other accepted methodologies. The Panel also concluded that the data are insufficient to determine the safety of Polyaminopropyl Biguanide in products that may be incidentally inhaled.

Original languageEnglish (US)
Pages (from-to)26S-73S
JournalInternational journal of toxicology
Volume39
Issue number3_suppl
DOIs
StatePublished - Nov 2020
Externally publishedYes

Keywords

  • cosmetics
  • polyaminopropyl biguanide
  • polyhexamethylene biguanide hydrochloride
  • safety

ASJC Scopus subject areas

  • Toxicology

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