Safety Assessment of PEGylated Alkyl Glycerides as Used in Cosmetics

Monice M. Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth

Research output: Contribution to journalArticlepeer-review

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 60 PEGylated alkyl glycerides. PEGylated alkyl glycerides are mono-, di-, and/or triglycerides that have been modified with ethylene glycol repeat units (in the starting material form as epoxide). Most of the PEGylated alkyl glycerides are reported to function as skin-conditioning agents or surfactants. The Panel reviewed the available animal and clinical data as well as data from the 1999 report for the 5 polyethylene glycol (PEG) glyceryl cocoates and the 2012 report of PEGylated oils, to determine the safety of these ingredients. The Panel concluded these ingredients are safe in the current practices of use and concentration when formulated to be nonirritating; this conclusion supersedes the 1999 conclusion issued on 5 PEG glyceryl cocoate ingredients.

Original languageEnglish (US)
Pages (from-to)26S-58S
JournalInternational journal of toxicology
Volume39
Issue number2_suppl
DOIs
StatePublished - Sep 1 2020

Keywords

  • PEGylated alkyl glycerides
  • cosmetics
  • safety

ASJC Scopus subject areas

  • Toxicology

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