Safety Assessment of Methyl Glucose Polyethers and Esters as Used in Cosmetics

Wilbur Johnson, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journalArticle

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methyl glucose polyethers and esters which function in cosmetics as skin/hair-conditioning agents, surfactants, or viscosity increasing agents. The esters included in this assessment are mono-, di-, or tricarboxyester substituted methyl glucosides, and the polyethers are mixtures of various chain lengths. The Panel reviewed available animal and clinical data, including the molecular weights, log Kows, and other properties in making its determination of safety on these ingredients. Where there were data gaps, similarities between molecular structures, physicochemical and biological characteristics, and functions and concentrations in cosmetics allowed for extrapolation of the available toxicological data to assess the safety of the entire group. The Panel concluded that there likely would be no significant systemic exposure from cosmetic use of these ingredients, and that these ingredients are safe in cosmetic formulations in the present practices of use and concentration.

Original languageEnglish (US)
Pages (from-to)12S-40S
JournalInternational journal of toxicology
Volume35
Issue number2_suppl
DOIs
StatePublished - Nov 1 2016

Keywords

  • cosmetics
  • methyl glucose polyethers
  • safety

ASJC Scopus subject areas

  • Toxicology

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    Johnson, W., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., Andersen, F. A., & Gill, L. J. (2016). Safety Assessment of Methyl Glucose Polyethers and Esters as Used in Cosmetics. International journal of toxicology, 35(2_suppl), 12S-40S. https://doi.org/10.1177/1091581816670322