Safety Assessment of Hydroxypropyl Bis(N -Hydroxyethyl- p -Phenylenediamine) HCl as Used in Cosmetics

Lillian C. Becker, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The Cosmetic Ingredient Review Expert Panel (CIR Panel) reviewed the safety of hydroxypropyl bis(N-Hydroxyethyl-p-Phenylenediamine) HCl, which functions as an oxidative hair dye ingredient. The Panel considered relevant animal and human data provided in this safety assessment and concluded that hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) HCl is safe for use in oxidative hair dye formulations as described in this safety assessment.

Original languageEnglish (US)
Pages (from-to)5S-11S
JournalInternational journal of toxicology
Issue number2_suppl
StatePublished - Nov 1 2016


  • hair dye
  • hydroxypropyl bis(N -hydroxyethyl- p -phenylenediamine) HCl
  • phenylenediamine

ASJC Scopus subject areas

  • Toxicology


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