Safety Assessment of Hydroxyethyl-3,4-Methylenedioxyaniline HCl as Used in Cosmetics

Laura N. Scott, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Bart Heldreth

Research output: Contribution to journalArticlepeer-review

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Hydroxyethyl-3,4-Methylenedioxyaniline HCl, which is reported to function as a hair dye ingredient. The Panel reviewed relevant data provided in this safety assessment, and concluded that Hydroxyethyl-3,4-Methylenedioxyaniline HCl is safe for use as a hair dye ingredient in the present practices of use and concentrations described in this report. The Panel cautions that this ingredient should not be used in cosmetic products in which N-nitroso compounds can be formed.

Original languageEnglish (US)
Pages (from-to)76S-90S
JournalInternational journal of toxicology
Volume41
Issue number2
DOIs
StatePublished - Aug 2022
Externally publishedYes

Keywords

  • Hydroxyethyl-3,4-Methylenedioxyaniline HCl
  • cosmetics
  • safety

ASJC Scopus subject areas

  • Toxicology

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