Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics

Monice M. Fiume, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalReview article

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of diethanolamine and its salts as used in cosmetics. Diethanolamine functions as a pH adjuster; the 16 salts included in this rereview reportedly function as surfactants, emulsifying agents, viscosity increasing agents, hair or skin conditioning agents, foam boosters, or antistatic agents. The Panel reviewed available animal and clinical data, as well as information from previous CIR reports. Since data were not available for each individual ingredient, and since the salts dissociate freely in water, the Panel extrapolated from previous reports to support safety. The Panel concluded that diethanolamine and its salts are safe for use when formulated to be nonirritating. These ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed.

Original languageEnglish (US)
Pages (from-to)89S-110S
JournalInternational Journal of Toxicology
Volume36
Issue number5_suppl2
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Keywords

  • cosmetics
  • diethanolamine
  • safety

ASJC Scopus subject areas

  • Toxicology

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    Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., & Andersen, F. A. (2017). Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics. International Journal of Toxicology, 36(5_suppl2), 89S-110S. https://doi.org/10.1177/1091581817707179