Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics

Monice M. Fiume, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 8 dialkyl sulfosuccinate salts for use in cosmetics, finding that these ingredients are safe in cosmetics in the present practices of use and concentration when formulated to be nonirritating. The dialkyl sulfosuccinate salts primarily function as surfactants in cosmetics. The Panel reviewed the new and existing available animal and clinical data in making its determination of safety. The Panel found it appropriate to extrapolate the data on diethylhexyl sodium sulfosuccinate to assess the safety of the entire group because all of the diesters are of a similar alkyl chain length, all are symmetrically substituted, and all have similar functions in cosmetic formulations.

Original languageEnglish (US)
Pages (from-to)34S-46S
JournalInternational journal of toxicology
Volume35
Issue number3_suppl
DOIs
StatePublished - Nov 1 2016

Keywords

  • cosmetics
  • dialkyl sulfosuccinate salts
  • safety

ASJC Scopus subject areas

  • Toxicology

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