Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics

Monice M. Fiume, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 131 alkyl polyethylene glycol (PEG)/polypropylene glycol ethers as used in cosmetics, concluding that these ingredients are safe in the present practices of use and concentration described in this safety assessment when formulated to be nonirritating. Most of the alkyl PEG/PPG ethers included in this review are reported to function in cosmetics as surfactants, skin-conditioning agents, and/or emulsifying agents. The alkyl PEG/PPG ethers share very similar physiochemical properties as the alkyl PEG ethers, which were reviewed previously by the CIR Expert Panel and found safe when formulated to be nonirritating. The alkyl PEG ethers differ by the inclusion of PPG repeat units, which are used to fine-tune the surfactant properties of this group. The Panel relied heavily on data on analogous ingredients, extracted from the alkyl PEG ethers and PPG reports, when making its determination of safety.

Original languageEnglish (US)
Pages (from-to)60S-89S
JournalInternational Journal of Toxicology
Volume35
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Fingerprint

Ethers
Cosmetics
Safety
Surface-Active Agents
Emulsifying Agents
Polyethylene glycols
Skin

Keywords

  • alkyl PEG/PPG ethers
  • cosmetics
  • safety

ASJC Scopus subject areas

  • Toxicology

Cite this

Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... Gill, L. J. (2016). Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics. International Journal of Toxicology, 35, 60S-89S. https://doi.org/10.1177/1091581816650626

Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics. / Fiume, Monice M.; Heldreth, Bart; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J; Snyder, Paul W.; Andersen, F. Alan; Gill, Lillian J.

In: International Journal of Toxicology, Vol. 35, 01.07.2016, p. 60S-89S.

Research output: Contribution to journalArticle

Fiume, MM, Heldreth, B, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, JG, Shank, RC, Slaga, TJ, Snyder, PW, Andersen, FA & Gill, LJ 2016, 'Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics', International Journal of Toxicology, vol. 35, pp. 60S-89S. https://doi.org/10.1177/1091581816650626
Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al. Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics. International Journal of Toxicology. 2016 Jul 1;35:60S-89S. https://doi.org/10.1177/1091581816650626
Fiume, Monice M. ; Heldreth, Bart ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J ; Snyder, Paul W. ; Andersen, F. Alan ; Gill, Lillian J. / Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics. In: International Journal of Toxicology. 2016 ; Vol. 35. pp. 60S-89S.
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