Safety Assessment of Alkyl PEG Sulfosuccinates as Used in Cosmetics

Wilbur Johnson, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the safety of alkyl polyethylene glycol (PEG) sulfosuccinates, which function in cosmetics mostly as surfactants/cleansing agents. Although these ingredients may cause ocular and skin irritation, dermal penetration is unlikely because of the substantial polarity and molecular size of these ingredients. The Panel considered the negative oral carcinogenicity and reproductive and developmental toxicity data on chemically related laureths (PEG lauryl ethers) and negative repeated dose toxicity and skin sensitization data on disodium laureth sulfosuccinate supported the safety of these alkyl PEG sulfosuccinates in cosmetic products, but. The CIR Expert Panel concluded that the alkyl PEG sulfosuccinates are safe in the present practices of use and concentration when formulated to be nonirritating.

Original languageEnglish (US)
Pages (from-to)70S-83S
JournalInternational Journal of Toxicology
Volume34
Issue number2
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Fingerprint

Cosmetics
Safety
Skin
Toxicity
Ethers
Surface-Active Agents
Detergents
thiosuccinic acid

Keywords

  • alkyl PEG sulfosuccinates
  • cosmetics
  • safety

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Johnson, W., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... Andersen, F. A. (2015). Safety Assessment of Alkyl PEG Sulfosuccinates as Used in Cosmetics. International Journal of Toxicology, 34(2), 70S-83S. https://doi.org/10.1177/1091581815594755

Safety Assessment of Alkyl PEG Sulfosuccinates as Used in Cosmetics. / Johnson, Wilbur; Heldreth, Bart; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J; Snyder, Paul W.; Andersen, F. Alan.

In: International Journal of Toxicology, Vol. 34, No. 2, 01.09.2015, p. 70S-83S.

Research output: Contribution to journalArticle

Johnson, W, Heldreth, B, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, JG, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2015, 'Safety Assessment of Alkyl PEG Sulfosuccinates as Used in Cosmetics', International Journal of Toxicology, vol. 34, no. 2, pp. 70S-83S. https://doi.org/10.1177/1091581815594755
Johnson W, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al. Safety Assessment of Alkyl PEG Sulfosuccinates as Used in Cosmetics. International Journal of Toxicology. 2015 Sep 1;34(2):70S-83S. https://doi.org/10.1177/1091581815594755
Johnson, Wilbur ; Heldreth, Bart ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J ; Snyder, Paul W. ; Andersen, F. Alan. / Safety Assessment of Alkyl PEG Sulfosuccinates as Used in Cosmetics. In: International Journal of Toxicology. 2015 ; Vol. 34, No. 2. pp. 70S-83S.
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