Safety Assessment of Alkyl Esters as Used in Cosmetics

Monice M. Fiume, Bart A. Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 237 alkyl esters for use in cosmetics. The alkyl esters included in this assessment have a variety of reported functions in cosmetics, with skin-conditioning agent being the most common function. The Panel reviewed available animal and clinical data in making its determination of safety on these ingredients, and where there were data gaps, similarity in structure, properties, functions, and uses of these ingredients allowed for extrapolation of the available toxicological data to assess the safety of the entire group. The Panel concluded that these ingredients are safe in cosmetic formulations in the present practices of use and concentration when formulated to be nonirritating.

Original languageEnglish (US)
Pages (from-to)5S-69S
JournalInternational Journal of Toxicology
Volume34
Issue number2
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

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Keywords

  • alkyl esters
  • cosmetics
  • safety

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fiume, M. M., Heldreth, B. A., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., & Andersen, F. A. (2015). Safety Assessment of Alkyl Esters as Used in Cosmetics. International Journal of Toxicology, 34(2), 5S-69S. https://doi.org/10.1177/1091581815594027