Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosmetics

Christina L. Burnett; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; Lillian J. Gill; Bart Heldreth

doi:10.1177/10915818221082093

Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosmetics

Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth

Pharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate, which functions as an oxidative hair dye ingredient. The Panel reviewed relevant data provided in this safety assessment, and concluded that 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate is safe in the present practices of use and concentration in oxidative hair dye formulations.

Original language	English (US)
Pages (from-to)	69S-79S
Journal	International journal of toxicology
Volume	41
Issue number	1
DOIs	https://doi.org/10.1177/10915818221082093
State	Published - Jun 1 2022

Keywords

biologics
ICH S6(R1)
long-term studies
non-rodent
rodent

ASJC Scopus subject areas

Toxicology

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10.1177/10915818221082093

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Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosmetics. / Burnett, Christina L.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Gill, Lillian J.; Heldreth, Bart.

In: International journal of toxicology, Vol. 41, No. 1, 01.06.2022, p. 69S-79S.

Research output: Contribution to journal › Article › peer-review

Burnett, Christina L. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Gill, Lillian J. ; Heldreth, Bart. / Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosmetics. In: International journal of toxicology. 2022 ; Vol. 41, No. 1. pp. 69S-79S.

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AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

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Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosmetics

Abstract

Keywords

ASJC Scopus subject areas

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