Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosmetics

Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth

Research output: Contribution to journalArticlepeer-review

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate, which functions as an oxidative hair dye ingredient. The Panel reviewed relevant data provided in this safety assessment, and concluded that 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate is safe in the present practices of use and concentration in oxidative hair dye formulations.

Original languageEnglish (US)
Pages (from-to)69S-79S
JournalInternational journal of toxicology
Volume41
Issue number1
DOIs
StatePublished - Jun 1 2022

Keywords

  • biologics
  • ICH S6(R1)
  • long-term studies
  • non-rodent
  • rodent

ASJC Scopus subject areas

  • Toxicology

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