SAD-A and AMPK kinases: The "yin and yang" regulators of mTORC1 signaling in pancreatic β cells

Jia Nie, Xiao Han, Yuguang Shi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

SAD-A kinase is a member of the AMPK-related family of kinases, which are under the control of LKB1 kinase. In the human kinome, SAD-A is most closely related to AMPK, a key energy sensor and master regulator of metabolism. In contrast to AMPK, little is known about the physiological function of the SAD-A kinase in metabolism. Recent studies using knockout mice have revealed a striking role of the SAD-A kinase in regulating dynamic functions of islet β cells, from glucose-stimulated insulin secretion (GSIS), islet β-cell size and mass, to GLP-1 response as the first tissue-specific effector of mTORC1 signaling. These studies suggest that SAD-A and AMPK kinase may function as the positive and negative regulators of mTORC1 signaling in islet β cells. Importantly, these findings have implicated SAD-A kinase as a novel drug target for the treatment of type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)3366-3369
Number of pages4
JournalCell Cycle
Volume12
Issue number21
DOIs
StatePublished - Nov 1 2013
Externally publishedYes

Keywords

  • AMPK-related kinase
  • GLP-1
  • Incretin
  • Insulin secretion
  • LKB1
  • Type 2 diabetes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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