Síndrome adyuvante por implante de prótesis mamarias de silicón (siliconosis) ¿una condición emergente?

Translated title of the contribution: Adjuvant syndrome of silicone breast prosthesis (siliconosis): An emerging condition?

Emely Karam, Rafael Muci-Mendoza

Research output: Contribution to journalArticlepeer-review


Silicone breast prosthesis has been associated with a variety of medical conditions or autoimmune diseases, which has coincidental relation with the implants insertion; it's loomed as a new and unknown pathology of the modern times. More than 87 % of symptomatic patients developed demyelination axonal neuropathy demonstrated by nerve and muscle biopsy; 22 % to 25 % have evidence of autoimmune thyroid disease. An a small group of patients (10.%-12.%) have primary central nervous system demyelination disease as, multiple sclerosis. The diagnosis of multiple sclerosis was corroborated by magnetic resonance imaging and cerebrospinal fluid analysis. Also, an other wide spectrum of immunological diseases have been observed, such as fibromyalgia, Hashimoto's thyroiditis, polymyositis, dermatomyositis, lupus erythematosus, rheumatoid arthritis, scleroderma, and the presence of autoantibodies. Finally, for symptomatic patients, an adjuvant syndrome of silicone breast prosthesis or implant is proposed as a unitary diagnosis. The authors presented two patients whom illustrated this entity.

Translated title of the contributionAdjuvant syndrome of silicone breast prosthesis (siliconosis): An emerging condition?
Original languageSpanish
Pages (from-to)154-161
Number of pages8
JournalGaceta Medica de Caracas
Issue number2
StatePublished - Apr 2011
Externally publishedYes


  • Autoantibodies
  • Chronic inflammatory demyelinating polyneuropathy
  • Dermatomyositis
  • Fibromyalgia
  • Hashimoto's thyroiditis
  • Lupus erythematosus
  • Multiple sclerosis-central demyelination
  • Polymyositis
  • Polyurethane
  • Rheumatoid arthritis
  • Scleroderma
  • Silica
  • Silicone
  • Silicone breast implants

ASJC Scopus subject areas

  • General Medicine


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