RXR-2, a member of the retinoid x receptor family in Schistosoma mansoni

Wendy J. Freebern, Edward G. Niles, Philip T. Loverde

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

A cDNA encoding a second full-length member of the Schistosoma mansoni RXR family (SmRXR-2) was identified. The nucleotide sequence of SmRXR-2 translates into a protein of 784 amino acids with a pI of 7.63 and an approximate mass of 78 kDa making it the largest reported RXR to date. Phylogenetic tree analysis provides evidence that SmRXR-2 is the most ancient full-length RXR identified. SmRXR-2 exhibits unique sequence features compared with other RXRs. RT-PCR results demonstrate that the SmRXR-2 gene is constitutively expressed and thus must play multiple roles throughout schistosome development in the vertebrate host.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalGene
Volume233
Issue number1-2
DOIs
StatePublished - Jun 11 1999

Keywords

  • Amino acid sequence data
  • Molecular evolution
  • RT-PCR

ASJC Scopus subject areas

  • Genetics

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