Abstract
A cDNA encoding a second full-length member of the Schistosoma mansoni RXR family (SmRXR-2) was identified. The nucleotide sequence of SmRXR-2 translates into a protein of 784 amino acids with a pI of 7.63 and an approximate mass of 78 kDa making it the largest reported RXR to date. Phylogenetic tree analysis provides evidence that SmRXR-2 is the most ancient full-length RXR identified. SmRXR-2 exhibits unique sequence features compared with other RXRs. RT-PCR results demonstrate that the SmRXR-2 gene is constitutively expressed and thus must play multiple roles throughout schistosome development in the vertebrate host.
Original language | English (US) |
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Pages (from-to) | 33-38 |
Number of pages | 6 |
Journal | Gene |
Volume | 233 |
Issue number | 1-2 |
DOIs | |
State | Published - Jun 11 1999 |
Externally published | Yes |
Keywords
- Amino acid sequence data
- Molecular evolution
- RT-PCR
ASJC Scopus subject areas
- Genetics