Routine CSF Analysis in Coccidioidomycosis Is Not Required

George Thompson, Sharon Wang, Robert Bercovitch, Michael Bolaris, Dane Van Den Akker, Sandra Taylor, Rodrigo Lopez, Antonio Catanzaro, Jose Cadena, Peter Chin-Hong, Brad Spellberg

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Although routinely done, there has been no evaluation of the utility of performing routine cerebrospinal fluid (CSF) examination in patients with active coccidioidomycosis and high complement fixation (IgG) antibody titers or other risk factors for disseminated infection. In our review 100% of patients diagnosed with coccidioidal meningitis had at least one sign or symptom consistent with infection of the central nervous system, headache was present in 100% of those with meningitis, while no patients without signs/symptoms of CNS infection were found to have coccidioidal meningitis, irrespective of antibody titers or other risk factors. Thus routine lumbar puncture may be unnecessary for patients with coccidioidomycosis who lack suggestive clinical symptoms.

Original languageEnglish (US)
Article numbere64249
JournalPloS one
Issue number5
StatePublished - May 22 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General


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