Roughness and hydrophilicity as osteogenic biomimetic surface properties

Barbara D. Boyan, Ethan M. Lotz, Zvi Schwartz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Successful dental and orthopedic implant outcomes are determined by the degree of osseointegration. Over the last 60 years, endosseous implants have evolved to stimulate osteogenesis without the need for exogenous biologics such as bone morphogenetic proteins. An understanding of the interaction between cells and the physical characteristics of their environments has led to development of bioactive implants. Implant surfaces that mimic the inherent chemistry, topography, and wettability of native bone have shown to provide cells in the osteoblast lineage with the structural cues to promote tissue regeneration and net new bone formation. Studies show that attachment, proliferation, differentiation, and local factor production are sensitive to these implant surface characteristics. This review focuses on how surface properties, including chemistry, topography, and hydrophilicity, modulate protein adsorption, cell behavior, biological reactions, and signaling pathways in peri-implant bone tissue, allowing the development of true biomimetics that promote osseointegration by providing an environment suitable for osteogenesis.

Original languageEnglish (US)
Pages (from-to)1479-1489
Number of pages11
JournalTissue Engineering - Part A
Volume23
Issue number23-24
DOIs
StatePublished - Dec 1 2017

Fingerprint

Biomimetics
Surface Properties
Hydrophilicity
Hydrophobic and Hydrophilic Interactions
Osteogenesis
Surface properties
Osseointegration
Bone
Surface roughness
Topography
Wettability
Bone and Bones
Tissue regeneration
Bone Morphogenetic Proteins
Dental Implants
Osteoblasts
Orthopedics
Biological Products
Proteins
Cell Communication

Keywords

  • Biomimetic
  • Implant
  • Mesenchymal stem cell
  • Osteoblast
  • Osteoclast
  • Titanium

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

Cite this

Roughness and hydrophilicity as osteogenic biomimetic surface properties. / Boyan, Barbara D.; Lotz, Ethan M.; Schwartz, Zvi.

In: Tissue Engineering - Part A, Vol. 23, No. 23-24, 01.12.2017, p. 1479-1489.

Research output: Contribution to journalArticle

Boyan, Barbara D. ; Lotz, Ethan M. ; Schwartz, Zvi. / Roughness and hydrophilicity as osteogenic biomimetic surface properties. In: Tissue Engineering - Part A. 2017 ; Vol. 23, No. 23-24. pp. 1479-1489.
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