Abstract
Purpose To describe the experience and results from the roll-in phase of the Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) study. Materials and Methods The CORAL roll-in database was used to describe the baseline characteristics of the patients in the roll-in cohort, all of whom underwent renal artery stent placement; to evaluate CORAL site performance; to compare estimates of lesion (stenosis) severity made by site interventionalists with the central CORAL angiographic core laboratory readings; and to report outcomes after renal artery stent placement. During the roll-in phase, 239 patients (mean age, 70.2 y ± 9.0; 49% male) underwent renal artery stent procedures. Angiographic core laboratory analysis of renal arteriograms was done, and participants were followed at 1 month and 9 months. Results Major angiographic complications were identified in 28 (13%) subjects. Kidney function remained unchanged at the short (2-4 weeks) follow-up interval. Improvement in systolic blood pressure with use of distal embolic protection devices (n = 161) did not show any clinical benefit over nonuse of such devices (n = 78) in this small series. At 9 months, there were significantly more endpoints reported by site in subjects with bilateral renal artery stenosis (P =.01) and prior history of stroke (P =.03). Conclusions In the roll-in phase of the CORAL study, a significant number of angiographic complications were identified. No effect was seen on estimated glomerular filtration rate after renal artery stent placement, but systolic blood pressure decreased significantly.
Original language | English (US) |
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Pages (from-to) | 511-520 |
Number of pages | 10 |
Journal | Journal of Vascular and Interventional Radiology |
Volume | 25 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2014 |
Keywords
- ASTRAL
- Abbreviations
- Angioplasty and Stenting for Renal Artery Lesions
- CKD
- CORAL
- Cardiovascular Outcomes with Renal Atherosclerotic Lesions
- DPD
- SAE
- STAR
- STenting in renal dysfunction caused by Atherosclerotic Renal artery stenosis
- chronic kidney disease
- distal embolic protection device
- eGFR
- estimated glomerular filtration rate
- serious adverse event
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging