Roles of transient receptor potential channels in pain

Cheryl L. Stucky, Adrienne E. Dubin, Nathaniel Jeske, Sacha A. Malin, David D. McKemy, Gina M. Story

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious stimuli and transduce a diverse range of physical and chemical energy into action potentials in somatosensory nociceptors. Here we highlight the roles of TRP vanilloid 1 (TRPV1), TRP melastatin 8 (TRPM8) and TRP ankyrin 1 (TRPA1) in the activation of nociceptors by heat and cold environmental stimuli, mechanical force, and by chemicals including exogenous plant and environmental compounds as well as endogenous inflammatory molecules. The contribution of these channels to pain and somatosensation is discussed at levels ranging from whole animal behavior to molecular modulation by intracellular signaling proteins. An emerging theme is that TRP channels are not simple ion channel transducers of one or two stimuli, but instead serve multidimensional roles in signaling sensory stimuli that are exceptionally diverse in modality and in their environmental milieu.

Original languageEnglish (US)
Pages (from-to)2-23
Number of pages22
JournalBrain Research Reviews
Volume60
Issue number1
DOIs
StatePublished - Apr 2009

Fingerprint

Transient Receptor Potential Channels
Nociceptors
Ion Channels
Pain
Intracellular Signaling Peptides and Proteins
Ankyrins
Animal Behavior
Pain Perception
Transducers
Action Potentials
Hot Temperature
Research

Keywords

  • Artemin
  • Bradykinin
  • Cold
  • Cutaneous
  • Inflammation
  • Kinase
  • Mechanotransduction
  • NGF
  • Nociceptor
  • Prostaglandin
  • Scaffold protein
  • Sensory neuron
  • TRPA1
  • TRPM8
  • TRPV1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Stucky, C. L., Dubin, A. E., Jeske, N., Malin, S. A., McKemy, D. D., & Story, G. M. (2009). Roles of transient receptor potential channels in pain. Brain Research Reviews, 60(1), 2-23. https://doi.org/10.1016/j.brainresrev.2008.12.018

Roles of transient receptor potential channels in pain. / Stucky, Cheryl L.; Dubin, Adrienne E.; Jeske, Nathaniel; Malin, Sacha A.; McKemy, David D.; Story, Gina M.

In: Brain Research Reviews, Vol. 60, No. 1, 04.2009, p. 2-23.

Research output: Contribution to journalArticle

Stucky, CL, Dubin, AE, Jeske, N, Malin, SA, McKemy, DD & Story, GM 2009, 'Roles of transient receptor potential channels in pain', Brain Research Reviews, vol. 60, no. 1, pp. 2-23. https://doi.org/10.1016/j.brainresrev.2008.12.018
Stucky, Cheryl L. ; Dubin, Adrienne E. ; Jeske, Nathaniel ; Malin, Sacha A. ; McKemy, David D. ; Story, Gina M. / Roles of transient receptor potential channels in pain. In: Brain Research Reviews. 2009 ; Vol. 60, No. 1. pp. 2-23.
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