Roles of Melatonin in Maintaining Mitochondrial Welfare Focus on Renal Cells

Feres José Mocayar Marón, Emiliano Diez, Russel J. Reiter, Walter Manucha

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Current knowledge highlights aspects never before suspected of melatonin, a known chrono-regulatory hormone initially described in the pineal gland is present in most tissues and fulfills fundamental protective functions in vital organelles such as mitochondria. In this sense, recent findings show that alterations of mitochondrial function are closely related to loss of melatonin regulation. This chapter describes the most innovative aspects of melatonin for mitochondrial welfare, with particular emphasis on the renal cells. Alterations in the mitochondrial signaling pathways associated with the loss of melatonin-mediated regulation induce in renal cells a functional decoupling with the development of renal and finally cardiovascular tissue pathology. Although it is an endogenous compound, melatonin would be a useful exogenous pharmacological tool for many diseases however, additional clinical trials are needed to demonstrate its translational power.

Original languageEnglish (US)
Title of host publicationHandbook of Mitochondrial Dysfunction
PublisherTaylor and Francis
Pages389-398
Number of pages10
ISBN (Electronic)9780429811777
ISBN (Print)9780429443336
DOIs
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General Medicine

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