Roles of DNA helicases in the mediation and regulation of homologous recombination

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Abstract

Homologous recombination (HR) is an evolutionarily conserved process that eliminates DNA double-strand breaks from chromosomes, repairs injured DNA replication forks, and helps orchestrate meiotic chromosome segregation. Recent studies have shown that DNA helicases play multifaceted roles in HR mediation and regulation. In particular, the S. cerevisiae Sgs1 helicase and its human ortholog BLM helicase are involved in not only the resection of the primary lesion to generate single-stranded DNA to prompt the assembly of the HR machinery, but they also function in somatic cells to suppress the formation of chromosome arm crossovers during HR. On the other hand, the S. cerevisiae Mph1 and Srs2 helicases, and their respective functional equivalents in other eukaryotes, suppress spurious HR events and favor the formation of noncrossovers via distinct mechanisms. Thus, the functional integrity of the HR process and HR outcomes are dependent upon these helicase enzymes. Since mutations in some of these helicases lead to cancer predisposition in humans and mice, studies on them have clear relevance to human health and disease.

Original languageEnglish (US)
Title of host publicationDNA Helicases and DNA Motor Proteins
PublisherSpringer New York LLC
Pages185-202
Number of pages18
ISBN (Print)9781461450368
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume767
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Daley, J. M., Niu, H., & Sung, P. (2013). Roles of DNA helicases in the mediation and regulation of homologous recombination. In DNA Helicases and DNA Motor Proteins (pp. 185-202). (Advances in Experimental Medicine and Biology; Vol. 767). Springer New York LLC. https://doi.org/10.1007/978-1-4614-5037-5_9