Roles and mechanisms of MicroRNAs in pancreatic cancer

Lidong Zhang, Md Saha Jamaluddin, Sarah M. Weakley, Qizhi Yao, Changyi Chen

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Pancreatic cancer (PC) is an aggressive malignancy with poor survival. The discovery of microRNAs (miRNAs) has provided a new opportunity to study the disease. Thus far, altered expression of miRNAs has been reported in a wide range of malignancies, including PC, and some miRNAs are associated with PC cell proliferation, invasion, chemoresistance, and patient survival. This review summarizes recent advances with respect to the roles and mechanisms of miRNAs in PC and discusses potential clinical applications.

Original languageEnglish (US)
Pages (from-to)1725-1731
Number of pages7
JournalWorld journal of surgery
Volume35
Issue number8
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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