Role of Wnt signaling in fracture healing

Huiyun Xu, Jing Duan, Dandan Ning, Jingbao Li, Ruofei Liu, Ruixin Yang, Jean X. Jiang, Peng Shang

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair.

Original languageEnglish (US)
Pages (from-to)666-672
Number of pages7
JournalBMB Reports
Volume47
Issue number12
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Fracture healing
  • GSK-3β
  • Sost
  • Wnt signaling pathway
  • β-catenin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Xu, H., Duan, J., Ning, D., Li, J., Liu, R., Yang, R., Jiang, J. X., & Shang, P. (2014). Role of Wnt signaling in fracture healing. BMB Reports, 47(12), 666-672. https://doi.org/10.5483/BMBRep.2014.47.12.193