Role of the sympathetic innervation in the cold-induced activation of 5'-deiodinase in brown adipose tissue of the Djungarian hamster

A. Meywirth, U. Redlin, S. Steinlechner, G. Heldmaier, R. J. Reiter

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The importance of the sympathetic innervation in the regulation of 5'-deiodinase activity in the interscapular brown adipose tissue (BAT) of the Djungarian hamster was studied. Interscapular BAT of Djungarian hamsters was either unilaterally or bilaterally denervated, and thereafter the animals were maintained at thermoneutral temperature or exposed to 0°C for 24 h. Denervation reduced the norepinephrine content to 2-10% of the level in the control groups. Unilateral denervation was as effective as bilateral denervation in depressing the norepinephrine content of the interscapular BAT. Cold exposure for 24 h resulted in a pronounced 5'-deiodinase activation. Denervation reduced, but did not completely prevent, the cold induced increase in 5'-deiodinase activity. The basal level of 5'-deiodinase activity at thermoneutral temperature was not reduced by denervation. We conclude that cold-induced activation of BAT 5'-deiodinase primarily depends on the intact sympathetic innervation.

Original languageEnglish (US)
Pages (from-to)1896-1900
Number of pages5
JournalCanadian Journal of Physiology and Pharmacology
Volume69
Issue number12
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Keywords

  • 5'-deiodinase
  • Phodopus sungorus
  • brown fat
  • nonshivering thermogenesis

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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